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Combating Chronic Pain Without Opiods – Cannabinoids like CBDV, CBC, CBN and CBD are Coming to the Rescue via their Activity on TRP Channels

Bully, Torturer, and Killer - Chronic Pain Must Be Stopped, as well as its Most Effective Antidote, Opiods TRP Channels Maybe because most of us are still trying to organize our thinking about CB1 and CB2 receptors, we haven't yet read the papers about Transient Receptor Potential (TRP) channels and how scientists are beginning

By |2020-10-09T11:35:48-07:00October 2nd, 2020|PPM News|

Part ll: PK and PD Curves Really Matter with Cannabinoids: CBD, CBC, CBN and THCV

Gummies, Softgels or Tinctures? Cannabinoids, the Human Liver, PK and PD Curves. By Andrea Holmes, Ph.D., Chief Growth Officer, Precision Plant Molecules Image credit: Edited from Shutterstock by Andrea Holmes Blood and Guts Metabolism is a broad term encompassing a wide range of biochemical processes in your body. Your metabolism can be considered a gatekeeper

By |2020-08-18T10:12:09-07:00August 17th, 2020|PPM News|

Why Do PK and PD Curves Matter with CBD, CBC, CBN and THCV?

Are you serious? Only 6-10% of the cannabinoids in my Gummy Bear engages my endocannabinoid system? By Andrea Holmes, Ph.D., Chief Growth Officer, Precision Plant Moleculs This article was originally published in the July-Aug 2020 issue of Extraction Magazine. Image credit: Modified from Shutterstock by Andrea Holmes Pharmacokinetic (PK) Curves Pharmacokinetic curves sound impressive. How

By |2020-08-13T08:35:26-07:00August 10th, 2020|PPM News|

CBC is an Ambidextrous Phytocannabinoid. Might it be the Next “It” Cannabinoid? What do snails have to do with CBC?

Why CBC is one of the Big "4": CBC, CBD, CBG and THC In PPM's previous newsletter, we talked about Cannabichromene (CBC) being chiral, having both a right- and left-hand molecule geometry. In Nature, it is fairly rare that she produces both stereoisomers in equal proportions. The chemical term for this equal ratio is

By |2020-07-10T07:52:25-07:00July 10th, 2020|PPM News|

Cannabinoids like CBC can be a “Righty” or a “Lefty” – But Let’s Keep Politics Out!

Don't worry, Naturally Occurring Molecules can be Chiral but such Phytocannabinoids are Not Making a Political Statement. Let's use Cannabichromene (CBC) as an example. First the Facts: 1. CBC is a naturally-occurring so-called "minor" cannabinoid and is increasingly in demand by formulators to make more effective remedies and medicines and may be an important contributor to the

By |2020-07-02T09:24:11-07:00July 2nd, 2020|PPM News|

The Poison is in the Dose: Cannabinoids (CBD, CBN, CBC, CBxyz!) vs Tylenol Toxicity – Part II

Let's consider what you have in your home and its toxicity as we judge cannabinoids. Please recall two important definitions in the study of toxicology: LD50 is defined as the "median lethal dose" of a substance that will kill 50% of those given that amount. NOAEL is defined as the amount of a substance

By |2020-05-30T14:01:56-07:00May 21st, 2020|PPM News|

The Poison is in the Dose: Safety Profiling CBD, CBN and the Minors – Part I

Sola Dosis Facit Venenum. "The dose makes the poison." Paracelsus, a Swiss physician and chemist, is credited for this maxim. He coined it 500 years ago. His famous dictum in its full glory is: "What is there that is not a poison? All things are poison and nothing is without poison. Solely the dose

By |2020-05-28T14:40:33-07:00May 18th, 2020|PPM News|

CBN, Carboxylesterase 1, P450, In Vitro – Huh?

Warning: Short, Technical, and No Worries if this Newsletter is not for you but only for the True Cannabinoid Geeks Dosing matters is obvious. Timing and mode of drug or supplement administration highly relevant. Even when and what you eat or drink makes a difference and can be problematic, positive, or neutral in terms

By |2020-04-27T08:01:14-07:00April 27th, 2020|PPM News|

Is THC-Free a Unicorn in the Land of Hemp and CBD?

Do THC-Free True Whole Hemp Plant Extracts, Oils and Distillates Really Exist? Why is the Concept of THC-Free So Darn Confusing? Read on if you want to learn how to translate product labels, decipher claims, and unravel marketing lingo that hopelessly confuses matters. We can’t promise this will be the most

By |2019-10-31T11:40:47-07:00October 31st, 2019|PPM News|

Beyond CBD: Emerging Cannabinoids are the Future for CPG Success

The buzz around the hemp-derived plant compound cannabidiol (CBD) and its therapeutic applications has captured more attention and interest than most other novel wellness products. A stampede is underway as mainstream retailers embrace hemp-derived CBD products. And cannabinoid science continues to advance at space velocity, further influencing and driving consumer trends. This presents a

By |2019-10-23T07:57:02-07:00October 23rd, 2019|PPM News|