Why CBC is one of the Big “4”: CBC, CBD, CBG and THC

In PPM’s previous newsletter, we talked about Cannabichromene (CBC) being chiral, having both a right- and left-hand molecule geometry. In Nature, it is fairly rare that she produces both stereoisomers in equal proportions. The chemical term for this equal ratio is racemic. The preference of “handedness” occurs in nature, evolution, and your body.

For example, the primordial soup only contained amino acids and sugars of one handedness, hearts are on your left side, and most of your DNA is right-handed. Left-handed helices have been produced experimentally and are only present in living cells in small amounts.

The direction of the shell coil in snails offers insight into the evolution of snails overall. A report published in Zoological Letters (1) states that snails do not normally develop to be right-handed, unless a specific rare gene is expressed.

Regarding CBC, scientific studies have yet to determine which “hand” or the equal ratio or even an uneven, “un-natural” ratio might have the most positive effect on the mammalian ECS system.

But whatever is determined in future research, in vivo and in human clinical trials, let’s cut to the chase of a quick survey of prior research on why we should care about CBC and its properties in its natural racemic form.

In various studies it has been shown that CBC exhibits potent activity against several Staphylococcus Aureus (MRSA) strains (2) and has anti-fungal properties (3). It has also been reported that CBC is superior in efficacy to phenylbutazone that is a nonsteroidal anti-inflammatory drug (NSAID) that has been discontinued for human use due to its strong side effects. (4)

CBC also interacts with proteins in the body that are responsible for pain control (5) and does not bind to the CB1 receptor in the endocannabinoid system, which means CBC does not induce feelings of euphoria. However, this rare cannabinoid binds to the CB2 receptor that modulates inflammation, (6) and also has the potential to be used in treating potential skin conditions, such as acne, because CBC has been shown to significantly decrease acne inducing lipids. (7)

CBC’s qualities have captured the attention of both researchers, health and wellness companies, the pharmaceutical industry and consumers because of the various studies showing the naturally occurring molecule’s potential to treat various health conditions. Some researchers state that CBC may also be useful in addressing various mental health issues and may prevent the absorption of endocannabinoid anandamide that has shown to have anti-tumor efficacy. (8 and 9)

All studies reported here have been published in the scientific peer-reviewed literature. From our survey and in our judgement, the articles cited are recent and relevant  to the potential health and wellness benefits of rare cannabinoids but does not include all literature that exists. It must be noted that most clinical trials have been performed on the animal model or in vitro on cells. More research is required including human trials to demonstrate and understand efficacy, serving and dosing sizes, potential side effects, effects on at-risk populations, and drug interactions related to the use of minor cannabinoids.

What Makes PPM Unique:

For several minor cannabinoids, including 100% hemp-derived CBN, we believe PPM is the only domestic producer of these naturally occurring minor cannabinoids selling kilos consistently and into highly demanding large company supply chains.

PPM is led by a team of advanced-degreed scientists with pharmaceutical industry and university research backgrounds representing over 100 years of chemistry and plant medicine experience.

PPM is committed to advancing the science and providing innovative true whole hemp plant extracts with fully customizable cannabinoid profiles, and minor and rare cannabinoid-based ingredients, both 100% hemp-derived and biosynthesized from hemp plant precursors versions including CBN, CBC, CBT, CBDA, THCV, CBDV, etc. to leading consumer product supply chains worldwide.

Clean. Consistent. Compliant.

Every day, every team member at PPM is inspired by the possibilities of plant-based medicine and remedies, and Mother Nature’s genius.

Krystle Jarrett
[email protected]