PPM’s CBG isolate is 100% hemp derived and over 98% pure. CBG is not scheduled as a controlled substance.
The purity of the CBG isolate has been tested by HPLC, LC-MS, GCMS, NMR, IR, melting point, and elemental analysis. All analytical test results demonstrated the high quality and purity of PPM’s CBG isolates.
PPM’s CBG isolate is processed in compliance with cGMP. It is available in kilo quantities.CBG is ideally suited for fully customizable bespoke formulations with other cannabinoids or terpenes that work synergistically through the entourage effect.
Published research has described the potential health and wellness benefits of CBG. Therefore, the popularity and demand for CBG has grown exponentially, and more and more cultivators are using new genetics to express this cannabinoid in larger amounts.
CBG and CBGA (the acidic form of CBG and its precursor) are known as the “Mother Cannabinoids” since the THC and CBD branches of the cannabis sativa’s family tree begin with the CBGA. The process of decarboxylation removes the carboxyl acidic group from the CBGA molecule resulting in CBG. The bioactivity in mammals can be quite different between the acidic form of a molecule or the non-acidic form, and sometimes only one or the other is bioactive. Heating is the common process to initiate the decarboxylation chemical process.
Contrary to the most well-known and studied psychotropic cannabinoid, THC, the CBG molecule is non-psychotropic and has a low affinity for the CB1 receptor in the endocannabinoid system. (Hyperlink 1) CBG also reacts with another non-endocannabinoid receptor which is responsible for CBG’s anti-inflammatory properties, possibly reducing neuronal deterioration in Parkinson’s disease. (Hyperlink 2)
Minor cannabinoids like CBG act on the endocannabinoid system of the skin and have therapeutic potential in connection with atopic dermatitis, psoriasis, scleroderma, acne, hair growth and pigmentation disorders, keratin diseases, various tumors, and itch. (Hyperlink 3 and 4) This is why CBG has gained the attention of the skin care and cosmetic industries for the cannabinoid’s preventative or restorative qualities that are anti-aging and promote healthy skin. Treating inflammatory skin conditions, sunburns and minor wounds are also being studied. In several research studies, CBG has been found to offer antimicrobial properties against methicillin-resistant Staphylococcus aureus (MRSA) strains (Hyperlink 5) and potential therapeutic value for psoriasis (Hyperlink 6), and acne (Hyperlink 7).
Minor cannabinoids like CBG may prove efficacious for sore muscles and joints, neuropathy, bursitis and tendinitis.
Of note, CBG has also been reported to promote apoptosis (cell death) and reduced growth of colon cancer cells, and can therefore be considered for possible prevention and cure of colon cancer. (Hyperlink 8)
- Hyperlink 1: https://www.mdpi.com/1420-3049/23/7/1526/htm#B50-molecules-23-01526
- Hyperlink 2: https://pubmed.ncbi.nlm.nih.gov/29338785
- Hyperlink 3: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429381/
- Hyperlink 4: https://www.ncbi.nlm.nih.gov/pubmed/30845666
- Hyperlink 5: https://pubmed.ncbi.nlm.nih.gov/18681481
- Hyperlink 6: https://pubmed.ncbi.nlm.nih.gov/17157480
- Hyperlink 7: https://pubmed.ncbi.nlm.nih.gov/27094344
- Hyperlink 8: https://www.ncbi.nlm.nih.gov/pubmed/25269802/
All studies reported here have been published in the scientific peer-reviewed literature. From our survey and in our judgement, the articles cited are recent and relevant to the potential health and wellness benefits of rare cannabinoids but does not include all literature that exists. It must be noted that most clinical trials have been performed on the animal model or in vitro on cells. More research is required including human trials to demonstrate and understand efficacy, serving and dosing sizes, potential side effects, effects on at-risk populations, and drug interactions related to the use of minor cannabinoids.