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News2019-10-24T08:32:04-07:00
1008, 2020

Why Do PK and PD Curves Matter with CBD, CBC, CBN and THCV?

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Are you serious? Only 6-10% of the cannabinoids in my Gummy Bear engages my endocannabinoid system? By Andrea Holmes, Ph.D., Chief Growth Officer, Precision Plant Moleculs Image credit: Modified from Shutterstock by Andrea Holmes Pharmacokinetic (PK) Curves Pharmacokinetic curves sound impressive. How about Maximal Plasma Concentration (CMax), Area Under the

1007, 2020

CBC is an Ambidextrous Phytocannabinoid. Might it be the Next “It” Cannabinoid? What do snails have to do with CBC?

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Why CBC is one of the Big "4": CBC, CBD, CBG and THC In PPM's previous newsletter, we talked about Cannabichromene (CBC) being chiral, having both a right- and left-hand molecule geometry. In Nature, it is fairly rare that she produces both stereoisomers in equal proportions. The chemical term

207, 2020

Cannabinoids like CBC can be a “Righty” or a “Lefty” – But Let’s Keep Politics Out!

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Don't worry, Naturally Occurring Molecules can be Chiral but such Phytocannabinoids are Not Making a Political Statement. Let's use Cannabichromene (CBC) as an example. First the Facts: 1. CBC is a naturally-occurring so-called "minor" cannabinoid and is increasingly in demand by formulators to make more effective remedies and medicines and may be

2105, 2020

The Poison is in the Dose: Cannabinoids (CBD, CBN, CBC, CBxyz!) vs Tylenol Toxicity – Part II

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Let's consider what you have in your home and its toxicity as we judge cannabinoids. Please recall two important definitions in the study of toxicology: LD50 is defined as the "median lethal dose" of a substance that will kill 50% of those given that amount. NOAEL is defined as

1805, 2020

The Poison is in the Dose: Safety Profiling CBD, CBN and the Minors – Part I

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Sola Dosis Facit Venenum. "The dose makes the poison." Paracelsus, a Swiss physician and chemist, is credited for this maxim. He coined it 500 years ago. His famous dictum in its full glory is: "What is there that is not a poison? All things are poison and nothing is

2704, 2020

CBN, Carboxylesterase 1, P450, In Vitro – Huh?

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Warning: Short, Technical, and No Worries if this Newsletter is not for you but only for the True Cannabinoid Geeks Dosing matters is obvious. Timing and mode of drug or supplement administration highly relevant. Even when and what you eat or drink makes a difference and can be problematic,

3110, 2019

Is THC-Free a Unicorn in the Land of Hemp and CBD?

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Do THC-Free True Whole Hemp Plant Extracts, Oils and Distillates Really Exist? Why is the Concept of THC-Free So Darn Confusing? Read on if you want to learn how to translate product labels, decipher claims, and unravel marketing lingo that hopelessly confuses matters. We can’t promise

2310, 2019

Beyond CBD: Emerging Cannabinoids are the Future for CPG Success

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The buzz around the hemp-derived plant compound cannabidiol (CBD) and its therapeutic applications has captured more attention and interest than most other novel wellness products. A stampede is underway as mainstream retailers embrace hemp-derived CBD products. And cannabinoid science continues to advance at space velocity, further influencing and driving

2409, 2019

Precision Plant Molecules Introduces the First Commercially Available High Purity Cannabichromene (CBC) Distillate to the Global Canna Marketplace

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CBC Distillate Oil (>90% purity and 0.0% THC) and cGMP-Processed is Now Available as a Bulk Ingredient or Add-in to CBD Extracts from Colorado-based PPM for Consumer Branded Products Companies Making Innovative, Effective and Distinctive Health and Wellness Products DENVER, Aug. 27, 2019 /PRNewswire/ -- Cannabichromene (CBC) continues to be studied

1308, 2019

Private Nebraska university to offer cannabis courses

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CRETE, Neb. (AP) — A private university in Nebraska, a state which bars recreational and medicinal marijuana, plans to offer an online program this fall that will cover the science, cultivation, processing and regulation of marijuana and hemp. Doane University in Crete will offer the three-course program, which will

307, 2019

Mother Nature’s Genius: Understanding Phytosynthesis Reveals Access to Naturally Occurring but Rare Minor Cannabinoids with Therapeutic Properties

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Mother Nature's Genius: Understanding Phytosynthesis Reveals Access to Naturally Occurring but Rare Minor Cannabinoids with Therapeutic Properties Because botanical medicine is inconsistent by Nature, Cannamimetics™ allows a smoothing and enhancement of the variability in extracts and concentrates made from plants, harvest to harvest, to ensure consumers are afforded the

2606, 2019

Should we give the FDA a Break?

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Plant Medicine and CBD Doesn’t Quite Fit Their Standard Operating Procedure The randomized, double-blind controlled studies that became standard in the 1950s for drug clinical trials are not well suited for multi-compound natural products because having more than one bioactive phytocompound exponentially increases the variables that need to be

2006, 2019

Hemp Family Tree and Cannamimetics

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Hemp Family Tree and Cannamimetics Cannamimetics simply means following Mother Nature’s lead. It is well known and extensively researched that during a hemp plant’s growth, various enzymatic, oxidation, photochemical and other bioprocesses produce cannabinoids and other bioactive compounds, transforming them during the course of the plant’s growth cycle. At

506, 2019

Greetings from Precision Plant Molecules (PPM)

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Greetings from Precision Plant Molecules (PPM) We are introducing PPM, a science-based, non-psychotropic cannabinoids processor and supplier, serving the most exacting consumer products companies worldwide as a trusted supply chain partner. PPM’s proprietary hemp extraction, refinement, purification technologies, and its state-of-the-art analytical testing and R&D lab instrumentation ensure its

305, 2019

Finally! Democrats and Republicans Agree on Something . . . CBD

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Top 10 Reasons Why The Red and Blue are Pro-CBD (and CBG, CBN, CBC) #10 The opioid crisis needs new pathways to decrease its tragic human consequences. CBD appears to be one such approach. #9 Pain hurts. Less pain is better. No one wants to be chronically inflamed. Is

2903, 2019

Garbage In, Garbage CBD Out

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Dirty CBD: Dirty, Dangerous and Dozens of Them Pesticides, Heavy Metals, Residual Solvents, Mycotoxins, Yeasts, Molds, E.Coli and Salmonella Great care and expertise (and of course accurate testing) from the field to the final CBD formulation must be taken by farmer and processor alike to ensure a safe and

1003, 2019

The Three Basics of a Trusted, Reliable, Consistent and Superior Quality Supply Chain Partner

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The Three Basics of a Trusted, Reliable, Consistent and Superior Quality Supply Chain Partner Is your CBD processor compliant with regulatory bodies? Do they document and verify all product and source materials? Do they prioritize their consumers, and thus, value safety above all else? Here are three basics that

803, 2019

Precision Plant Molecules Frustrated with your Third-Party Test Results?

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Precision Plant Molecules Frustrated with your Third-Party Test Results? Have you ever wondered why different third-party testing labs can test the same samples or batches, but then provide varying test results? Have your potency results ever been reported as > 100% CBD? LET’S SHED SOME LIGHT ON THESE MYSTERIES.

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